{"product_id":"manufacturing-of-gene-therapeutics-met","title":"Manufacturing Of Gene Therapeutics : Met","description":"Advances in molecular biology and recombinant DNA technology  have accelerated progress in many fields of life science research,  including gene therapy. A large number of genetic engineering  approaches and methods                            are readily available for gene cloning and  therapeutic vector construction. Significant progress is being made in  genomic, DNA sequencing, gene expression, gene delivery and cloning.  Thus gene therapy has already shown that                            it holds great promise for  the treatment of many diseases and disorders. In general it involves  the delivery of recombinant genes or transgenes into somatic cells to  replace proteins with a genetic defect or to transfer                            with the  pathological process of an illness. The viral and non-viral delivery  systems may hold the potential for future non-invasive, cost-effective  oral therapy of genetically-based disorders. \u003cbr\u003e  Recent years                            have seen considerable progress in the discovery and  early clinical development of a variety of gene therapeutic products.  The availability, validation, and implementation of gene therapeutic  products has also enabled                            success in testing and evaluation. New  challenges will need to be overcome to ensure that products will also  be successful in later clinical development and ultimately for  marketing authorisation. These new challenges will                            include  improvements in delivery systems, better control of in-vivo targeting,  increased level transduction and duration of expression of the gene,  and manufacturing process efficiencies that enable reduction in  production                            costs. Perhaps profound understanding of regulated gene  design may result in innovative bioproducts exhibiting safety and  efficacy profiles that are significantly superior to those achieved by  the use of naturally occurring                            genes. This procedure may contribute  considerably to fulfilling standards set by regulatory authorities.  \u003cbr\u003e  This book provides an overview of the current advances in the field of  gene therapy and the methods that                            are being successfully applied in  the manufacture of gene therapeutic products, and hopefully will  stimulate further progress and advancement in this field to meet the  ever-increasing demands.","brand":"MediaPlace","offers":[{"title":"Default Title","offer_id":57311897944446,"sku":"NW9780306466809","price":153.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1379\/1261\/files\/9780306466809.jpg?v=1778585344","url":"https:\/\/mediaplace.com\/en-eu\/products\/manufacturing-of-gene-therapeutics-met","provider":"MediaPlace","version":"1.0","type":"link"}